The agency said Tuesday the raids were made with other law enforcement agencies and stemmed from tips.
Immigrants who are entering the country illegally are usually warehoused in homes near the border until they can arrange the next leg of their journey north.
Border Patrol says the largest bust Monday in Mission resulted in the arrests of two suspected smugglers and 78 immigrants.
Other operations were interrupted in San Juan, Donna, Brownsville and at a motel in downtown McAllen where 21 immigrants were found.
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