The former "Friends" star will be on duty for a three-episode arc, joining series regulars including Zach Braff, Sarah Chalke, Donald Faison and John C. McGinley.
"Scrubs" marks a comedy encore for the 44-year-old Arquette, who, after the long-running "Friends," more recently starred as a tabloid-magazine boss on the FX network melodrama, "Dirt."
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