Houston police said officers responded to a call about the hit-and-run in west Houston and found the woman dead at the scene.
Investigators said they are checking video from businesses in the area that might help get a vehicle description.
Police are trying to determine whether the victim was walking in the median or on one of the main lanes before being struck by the vehicle.
Homer Lopez appeared before a judge for the first time since Thursday's incident in a restaurant parking lot.
Deputies say the driver is accused of intentionally running over five people, including his 35-year-old mother who died at the scene.
Police are clearing the scene after 2 have died following a wrong-way driving crash in Pasadena.
