All eastbound lanes along the South Loop near Telephone Road are shut down due to the major crash and spill, according to TranStar.
SkyEye was overhead after BWC Terminals said a damaged tank released sulfuric acid into the Houston Ship Channel, but the exact amount was unknown.
WCSO advised drivers to avoid the area near the intersection of Magnolia Road and Macedonia Road following a hazmat crash.
Multiple staff members were treated, and one was taken to the hospital after multiple explosions at the Montgomery County Sheriff's Office Crime Lab evidence incinerator, officials say.
Highway 146 and Spur 330 are reopened after a tanker leak forced all lanes to be closed for several hours on Wednesday, according to Baytown city officials.
Two separate heavy truck crashes caused backups for drivers along the North Freeway Thursday morning. Both incidents have since cleared.