Police say the shooting happened on Idaho Street near Yellowstone. Three men and a woman, as well as the infant, were hit in the gunfire.
A woman who carried the baby fled the scene, driving to a safe area to call 911.
All five were taken to the hospital and are expected to survive.
Investigators are now talking to neighbors to see if anyone saw anything.
Authorities tell Eyewitness News 80 shots were fired from two vehicles into a crowd of people.
The bullets landed all over the place. A car was hit by at least three shots. Shell casings still litter the scene. There are bullet holes in several cars on Idaho Street.
Resident Nina Benoit said, "We all got on the floor, my kids, I got three kids, my sister here, my mom, we just all got the floor."
Benoit lives across the street from the home targeted during the drive by shooting, but her cars were hit by flying bullets too. She says the shooting happened in two waves.
Benoit recalled, "My kids were so scared and crying because it was loud, it was like it was in our living room."
Reginald, who lives near the shooting scene, said, "Well, when I heard so many shots like I said, I just started to duck down because I didn't know where the bullets were headed to."
Police do not know why the shooting started, and they do not know how many people were firing weapons.
Some residents have had enough.
Benoit said, "We are moving, I don't want to stay here anymore, that's too close for comfort."
Police are looking for two vehicles that took part in the drive by shooting. A dark colored SUV and a white Ford F-350.
The suspects are described only as black males.
Anyone with information in this case is urged to contact the HPD Homicide Division at 713-308-3600 or Crime Stoppers at 713-222-TIPS.