Landry Jones threw for 321 yards and two touchdowns, and fullback Trey Millard had a career-best 119 yards receiving as the Sooners (4-1, 2-1 Big 12) added another rout to Bob Stoops' impressive rivalry resume.
Stoops is now 9-5 against Mack Brown and responsible for three of Oklahoma's five most lopsided wins over Texas -- and that doesn't include last year's 55-17 clobbering.
The Longhorns (3-2, 1-2) couldn't get a stop and never got their offense going, then lost quarterback David Ash to an apparent left wrist injury in the fourth quarter.
He headed to the locker room, pointing to the sky with his right hand and a towel over his bruised and swollen left wrist. Ash grasped at his left hand after getting hit by Oklahoma's Chuka Ndulue after he'd released what turned out to be his final pass attempt of the game.
Already losing 49-8 with 9:48 remaining, it only made a bad day worse for Texas.
Case McCoy relieved him and threw late touchdown passes to Mike Davis and John Harris against the Sooners' backups. Carrington Byndom returned an interception for a touchdown just after halftime, but it didn't create a spark for the Longhorns.
Defensive tackle Casey Walker planted an OU flag at midfield, and Jones donned the Golden Hat trophy as the Sooners celebrated another win that blends right in with Stoops' other big triumphs: 65-13 in 2003 and 63-14 in 2000.
Oklahoma ended up with a 677-289 advantage in total yardage, with 343 yards on the ground. A Texas defense that had high expectations at the start of the season has now given up 1,186 yards rushing in the past five weeks, with back-to-back losses that could knock them out of the Big 12 race.
Williams and Millard delivered the back-breaking plays. After Texas' second of four straight three-and-outs to start the game, Williams zipped through a hole on the right side of the line and got a smashing block from receiver Kenny Stills against Quandre Diggs to clear the way for the longest run in the rivalry's 107 games.
Millard then went hurdling over safety Mykkele Thompson to turn a short pass into a 73-yard gain and set up Bell's third score as the Sooners reeled off 23 straight points in the second quarter.
The Longhorns were being outgained 314 yards to 14 at that point.
All that kept Texas from a completely inept first half was a botched extra-point snap by the Sooners after their first touchdown, allowing Chris Whaley to block Michael Hunnicutt's kick and Diggs to return it for a 2-point conversion.
Even when there was a tiny glimmer of hope for the Longhorns, Oklahoma quickly snuffed it out.
Davis provided the first Texas first down with a leaping 31-yard catch along the sideline, getting up and pumping his arms to try to get his teammates fired up. But on the very next play, Ash tried to go deep again and Aaron Colvin picked off his pass.
The Sooners didn't score on that drive, but Justin Brown downed Tress Way's punt at the 1-yard line and a horde of Oklahoma players converged to take down Joe Bergeron for a safety on the next play. Williams ran right through the Longhorns to set up Bell's fourth touchdown run -- a 1-yarder that had him backing his way in for a 36-2 advantage.
Bell's first TD was an 8-yarder, one play after he'd converted on a fourth-and-1, and the other three were each from 1 yard out.