Amanda Maynard Murphy, 36, was arrested in Tennessee.
13 Investigates a Houston-area connection to what the FBI is calling one of the "biggest Medicare scams in history."
Agents accuse her of committing $100 million in fraud through a kickback scheme.
Prosecutors said a Houston-area clinic owner and other co-conspirators submitted $906 million in fraudulent Medicare and Tricare claims, with much of the money going to her lavish lifestyle, including a multi-million dollar home in Hawaii and the construction of a $4.6 million resort in the Philippines.
Comedian Carlos Mencia has been charged with 12 felony tax counts, Los Angeles County District Attorney Nathan Hochman announced Thursday.
A traffic stop in Chambers County led deputies to what they said is an international operation targeting senior citizens.