The media mogul teamed up with food giant Kraft Heinz to launch the line after creating a joint venture earlier this year.
The new brand, called O, That's Good!, will offer comfort foods with added vegetables, such as mashed potatoes with cauliflower mixed in. A broccoli cheddar soup has butternut squash to replace some cheese.
"This product line is real, delicious food with a twist," Winfrey said in a statement Wednesday.
Kraft Heinz Co. said the new brand has no connection to Winfrey's deal with Weight Watchers and won't mention the weight loss program on its packaging. Winfrey bought a 10 percent stake in Weight Watchers two years ago and appears in its ads.
The Oprah-branded soups and side dishes, priced below $5 each, will come to some supermarkets this week and be available nationwide by October.
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