The Big 12 regular season champions stayed competitive with the five-time national champions in Dallas, where a 54-51 loss derailed Houston's March Madness run.
The 6-foot-4-inch All-American, Big 12 Defensive Player of the Year and conference Player of the Year took an awkward step on a drive to the basket, rolled his right ankle, and went down in pain.
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Shead left the game with 6:38 left in the first half, having to be helped off by two trainers.
The game broadcast reported before halftime that Shead was questionable to return. X-rays were negative for any extensive damage, and the team called it a severely spained ankle.
The broadcast stated that the door was open for a return, but he remained on the bench throughout the second half.
Houston's defense still forced 14 Duke turnovers.
This marks the second straight Sweet Sixteen exit for the program.
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More coverage on UH's March Madness run
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- UH March Madness roundup: How to get Sweet 16 tickets, and No. 1 Coogs' tribute to Reggie Chaney
- No. 1 Houston survives OT thriller vs. A&M, heads to Sweet 16
- How message of UH guard Shead's parents impacted program
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- Houston Cougars guard Jamal Shead earns All-America 1st-Team honor ahead of 2024 March Madness
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