Patrol officers responded to a home on Lone Oak Road after receiving a family disturbance call and found a man dead inside the home.
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Sgt. Michael Ritchie of HCSO learned the man and his wife got into an argument, where the police said the woman pulled out a gun and shot him.
Officials did not elaborate on whether it was a physical or verbal fight and if the shooting was self-defense.
HCSO said there were children present when the shooting occurred. HCSO did not specify their relationship to the married couple.
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Ritchie said all present were interviewed, and an investigation is currently ongoing.