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The Houston Police Department said the fatal crash happened at about 12:55 a.m. at 5500 Southwest Freeway.
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According to witnesses, a black Nissan Versa was going westbound on the freeway when its driver failed to stay in a single lane and hit the impact traffic barrels at the Fountain View Drive exit ramp.
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The car bounced and hit the concrete wall barrier on the right shoulder.
When paramedics arrived, police said the man behind the wheel was pronounced dead at the scene.
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HPD said the passenger was transported to the hospital with non-life-threatening injuries.
Authorities said the identity of the 45-year-old victim is pending verification by the medical examiner's office as the investigation continues.
Police did not say whether seat belts were worn during the crash.
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