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The Houston Police Department confirmed the fatal crash happened just before 3 p.m., blocking all mainlanes of I-10 westbound at Federal, which were reopened by 6 p.m.
HPD said the incident involved two separate vehicles, though it's unclear how the motorcyclist died.
Drivers are urged to seek alternate routes as authorities investigate the crash.
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This is the second incident involving a motorcyclist killed in a crash on Tuesday. A 20-year-old man on a blue Kawasaki motorcycle hit the back of two cars after riding in between two lanes on US-59.
READ MORE: Motorcyclist dies after crashing into separate vehicles along US-59 inbound at Fondren, HPD says
Deadly crash involving motorcycle and SUV blocks 3 lanes of US-59 inbound at Fondren