At about 6:30 p.m. on Friday, Galveston police began an investigation of a fatal crash near 41st Street and Avenue O across from Ball High School.
The person who died is a juvenile, but authorities did not release the age or description of the victim.
Police have not confirmed whether any of the injured victims are students or school staff.
When the crash occurred, it was reported that the Ball High School's football team and support groups were on the road for a varsity game in Texas City.
Police believe alcohol was a factor in the crash. Witnesses told officers they saw a white Toyota SUV traveling at a high rate of speed before the wreck.
The incident marks the latest fatal crash on the island related to impaired driving in recent weeks.
The most recent incident involved a man on a scooter who was hit on Aug. 18.
Before that, on Aug. 6, two children and two adults - all part of the same family - died when the golf cart they were in was hit by a driver.
SEE MORE: 2 children, 2 adults killed after drunk driver crashes into golf cart in Galveston, police say
2 children, 2 adults killed after drunk driver crashes into golf cart in Galveston, police say
Scooter crash marks Galveston's 5th death in DUI wrecks in over a week
Scooter crash marks Galveston's 5th death in DUI wrecks in over a week