The repair is taking place on the northbound lane of Highway 146 and is expected to take until at least Monday morning, according to TxDOT.
TxDOT tweeted the following photo of the cracked pavement that needs repairing.
SEE RELATED STORY: Alligator creates traffic delay on Fred Hartman Bridge
Several more lanes may need to be shut down for the road work. No major delays have been reported.
The bridge spans the Houston Ship Channel between La Porte and Baytown.
SEE RELATED: History of Fred Hartman Bridge