Sgt. Jeff Murdock with Galveston PD said officers attempted to make a traffic stop, but the driver did not cooperate.
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A small chase ensued down the Seawall until it ended near 8th Street, where the pickup truck slammed into a vacant home on Winnie St.
In a video taken at the scene, the home's balcony is seen falling apart after the truck is lodged on the home's first floor.
Police said a female passenger was in the truck at the time of the crash. She was uninjured and released to family members.
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The driver was taken to UTMB out of caution to be checked out. Officials are not investigating if alcohol was a factor.