Harris County Precinct 5 said the incident happened at about 2:10 a.m. in the 8500 block of the Katy Freeway.
Preliminary information indicates that a driver in a Honda was allegedly going the wrong way before hitting a Toyota Camry head-on.
Deputies said two people were in the Honda and one in the Camry. All three were pronounced dead.
Video at the scene shows the heavy damage to both cars along the toll lanes of the freeway.
Pct. 5 said it was unclear which direction the Honda was going.
SEE ALSO: Man killed after being hit by wrong-way driver on Beltway 8 in east Harris County, sheriff says