It happened in the 16400 Block of Wood Drive on Monday evening.
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Firefighters were called to the area just before 6:30 p.m. when the fire erupted in the trailer, said the Channelview Fire Department.
CPR was administered to a man and a woman inside the trailer, and they were both taken to a nearby hospital, according to the Harris County Fire Marshal's Office.
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The man died shortly after in the hospital, and the woman remains in serious condition, according to authorities.
Authorities confirmed Tuesday afternoon that the fire was caused by a water heater.