The Houston Police Department said the shooting happened on Wild Indigo Street in west Houston near I-69.
Investigators said the woman was shot multiple times, including in the face, before her husband fled the scene.
She was rushed to the hospital, where police say she died.
If you know anything about this case, authorities urge you to contact the Houston Police Department's Homicide Division at (713) 308-3600.
If you need help getting out of a domestic violence situation, call the Houston Area Women's Center 24/7 hotline at 713-528-2121 or call AVDA at 713-224-9911. You can also click here to chat with an advocate online. If you are deaf or hard of hearing and need help, call 713-528-3625.