All southbound lanes of Highway 59 will close at Highway 288, TxDOT said. Officials said crews will also close the southbound 288 ramp to 59.
The closures are expected to last until Monday morning's rush.
Last weekend, crews closed the opposite side of the freeway to take down the bridge to make room for the major I-45 makeover.
READ RELATED: Alabama Street bridge closing for a year; U.S. 59 northbound closes for the weekend
The bridge connects Midtown and Third Ward.
TxDOT says that the bridge should reopen early next year.
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