The Harris County Sheriff's Office said the incident happened at about 9:30 p.m. along Highway 6 near Timber Creek Place Lane.
Investigators said the man in the wheelchair was outside of a crosswalk when he was hit by a white 2018 Ford F-150. The truck driver, identified as Christopher Baxter, initially didn't stop and drove home, HCSO said.
Deputies said the victim was hit once again by a silver 2013 Ford Focus. The driver of that vehicle, identified as Laura Peikert, also went home.
RELATED: Person in wheelchair killed trying to cross street in SE Houston
Person in wheelchair killed trying to cross street in SE Houston
HCSO said that about 30 minutes later, the first driver, Baxter, returned to the scene in another vehicle and cooperated with investigators.
Baxter was arrested for driving while intoxicated, but authorities said those charges could be upgraded.
Peikert, who also came back in a different vehicle, showed no signs of intoxication, deputies added.
"We'll complete a thorough investigation and reconstruction of the crash and present the case to the district attorney's office to see if those charges will be upgraded to a felony," Sgt. Bondurant said. "At this time, he'll be charged with DWI."
The sheriff's office warns against crossing busy roads, especially at night.
"If you're gonna cross in an intersection, especially one like Highway 6 and especially at night, make sure you use the intersection," Bondurant added. "They're there to protect you."