The crash happened at about 11 p.m. Thursday in the 10000 block of the La Porte Freeway near Allen Genoa Road.
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HPD says the driver, identified as a 30-year-old man, in a white Pontiac G6, was heading eastbound in the wrong direction on the westbound lanes of the freeway before he struck a man in a Ford Mustang.
Video from the aftermath of the wreckage shows the two mangled cars, with one bursting into flames in the middle of the road.
The wrong-way driver was pronounced dead at the scene. The driver of the Mustang, a 25-year-old, was taken to the hospital, where HPD said he was stable.
Officials did not say if they suspect alcohol was a factor.
An investigation into the case continues.
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