The crash happened near the city's Energy Corridor District around 1 a.m.
Police said the victim was stalled in a flowing lane of traffic in the westbound lanes near the Eldridge Parkway exit, changing a flat tire when another car came from behind and hit the man.
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Video captured at the scene showed the cars with heavy damage to the front end, showing just how hard the cars collided with each other.
The man who was hit was pronounced dead at the scene, according to HPD.
Police said the other vehicle's driver and other witnesses stayed on the scene and were interviewed by officers.
All the main lanes were shut down as officers worked to clear the scene.
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Officials warn drivers not to leave their cars if they break down while driving on busy roads. However, if it is safe, move the vehicle to the shoulder or a nearby parking lot.