The crash, first reported at about 5:50 a.m. by Houston Transtar, cleared about seven hours later.
SkyEye flew over the area during the morning commute and saw crews placing a drying agent over the spill.
It wasn't immediately known what led up to the crash, but Houston Transtar said it involved an 18-wheeler, box truck and two other vehicles.
Hours later, only the 18-wheeler remained pulled off to the side.
There's no word on whether anyone was injured.
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