Just before 4 a.m. on Saturday, fire officials responded to Rebecca Street near Bauman and saw smoke flames engulfing a home.
District Chief Kevin Carley with HFD said firefighters initially had difficulty entering the home because the windows and doors had burglar bars. After gaining entry, the couple was found by firefighters inside a bedroom.
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EMS officials began life-saving efforts on both of them before taking them to the medical center, HFD said.
Hours after the fire, the Houston Police Department said the man and woman did not survive.
Officials said the couple has lived in the area for years and were loved by all in the neighborhood.
HPD confirmed that the victim's son and the neighbor's grandson lived next door, which is who noticed the fire.
As officials swept the home, fire crews said they saw no smoke detectors. Chief Carley said that although they didn't find any, that doesn't necessarily mean they weren't present.
HPD says there is no foul play involved, and initial signs point to the fire possibly starting in the couple's living room.
Editor's Note: An earlier version of this story said that the victims' grandson called 911, according to investigators. That was incorrect. It was the neighbor's grandson.