HPD said the deadly crash happened just before 6 a.m. along the North Sam Houston Parkway East service road and West Hardy Road when a man riding a bike was hit by an 18-wheeler.
The driver of the 18-wheeler is accused of failing to stop and render aid and is now wanted by police.
Police said a witness did stop and called 911 to report the crash.
However, when paramedics arrived, authorities said they pronounced the victim dead.
The victim was 53 years old, and his identification is pending verification by the medical examiner's office.
Anyone with information on the wanted vehicle and the identity of the wanted driver is urged to contact the HPD Hit and Run unit at 713-247-4072 or Crime Stoppers at 713-222-TIPS.