The crash appeared to have happened on the overpass that crosses over the Westpark Toll Road.
ABC13 cameras captured what appears to be a damaged Toyota sedan and an HPD patrol vehicle in the middle of the road.
Officials did not say what led to the crash, or if there were any other suspects involved.
The status of the officer involved was not immediately known.
HCSO said it is investigating the crash.
ABC13 is following this developing story and will update as soon as more information becomes available.