The property, off the East Freeway in Channelview, is home to the now-vacant Fairfield Inn & Suites.
Officials say the hotel has been vacant for nearly a year.
Last May, investigators said a fire was caused by someone using a torch-style lighter to set a fire inside the hotel.
In total, fire officials say they've responded to seven major fires since March last year.
READ RELATED: Vacant Channelview hotel caught in major fire for the 7th time in the last year, according to HCFMO
This includes a fire last month, which destroyed most of the building.
Squatters, officials say, have caused multiple issues.
Harris County Pct. 2 says getting rid of the hotel is part of a $500,000 investment to "address dangerous properties and improve public safety."
The demolition is set to start around 10 a.m.
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