Officers said just before 11:30 p.m. on Friday, a man ran across the street near Briargrove and was struck by an SUV.
The man succumbed to his injuries while en route to the hospital, police said.
Investigators said the man was not using a crosswalk, and the driver stayed at the scene.
This is not the first deadly crash along this stretch of Westheimer.
ABC13 has reported on at least two others in the past year.
A woman was killed last November by a driver who police believe was intoxicated.
And last March, police say a husband and wife were hit and killed by a suspected intoxicated driver.
Police are urging people to use crosswalks.
READ MORE: Driver charged in fatal crash that killed husband and wife in west Houston Sunday