At 1:20 p.m., Houston TranStar verified a crash involving at least three vehicles, and shortly after, at 1:37 p.m., another crash involving nine vehicles was verified at the same spot.
The chain-reaction crashes, at IH-45 North northbound at SH 249 Mount Houston Road, were cleared at 3:18 p.m., according to Houston TranStar.
The Houston Fire Department said an SUV flipped and a minivan, an 18-wheeler, and an RV were among the chain crash.
First responders told Eyewitness News that at least five people were transported to the hospital.
The severity of the injuries is unknown, but HFD said they were told someone suffering a broken nose.
SkyEye video shows investigators scoping out the scene after crews speedily cleared the roads.
It is unclear what caused the major wreck.
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