Back in November, around 200 students walked out of class after a viral audio recording.
Students say some staff members were heard making inappropriate comments.
At that time, HISD temporarily reassigned several employees.
ORIGINAL REPORT: Houston ISD confirms investigating viral video that prompted Madison High School walkout
HISD acts hours after Madison HS students walk out of classes
At Tuesday night's board meeting, trustees approved the resignation of Carlotta Brown, who served as the school's principal.
An interim principal started last month, according to the district.
November 2021 was not the first time students walked out at Madison High School.
Back in 2019, Eyewitness News reported on a demonstration involving about 200 students who protested in response to an alleged incident on campus.
FROM 2019: Madison HS students walk out in protest over incident involving teen
HISD students walk out after incident involving teen