The search and rescue team say the vehicle was found in the Trinity River. EquuSearch said they also found a body inside.
The 48-year-old woman was last seen on Jan. 2, leaving her Houston home. She was driving a gray, 2012 Chrysler with Texas plates LKJ-0423.
RELATED: Houston woman was 'upset' before disappearing: police
Houston police said Perkins made several phone calls near Highway 146 and Highway 787 near Rye, in north Liberty County.
According to investigators, Perkins sounded upset during a call made just before she disappeared.