METRO Police said the crash happened around 5 a.m. on Memorial Drive at Shepherd Drive.
A bus contracted by a service called Transdev was struck head-on by a Jeep traveling the wrong way, police said.
Two people in the Jeep and the driver of the bus were hurt and taken to the hospital. Two passengers on the bus were transported to be checked for injuries, officials said.
A photo from a witness at the scene shows the front of the bus smashed. The Jeep that was reportedly driving the wrong way was heavily damaged.
Video shows firefighters prying open the door of the Jeep to get to the injured occupants.