The crash was reported at 6:21 a.m. in the southbound lanes near FM-517, according to Houston Transtar. The freeway reopened at 8:20 a.m.
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That stretch of I-45 is a construction zone, though it's unclear if that contributed to the crash.
Transtar said nine vehicles were involved, though at one point, SkyEye counted 15 vehicles stopped at the scene, and at least 11 of them had visible damage.
Backups stretched for miles. Emergency crews and tow trucks were among the drivers who were stuck in the traffic mess.
It's unclear what exactly led up to the pileup or if any injuries were reported.
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