The Houston Police Department said at about 6 p.m., officers responded to a person down call at a home on Erby Street near Duval.
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According to detectives, a male victim was found with a gunshot wound to the head in a closet.
HPD said two family members may have gotten into a disagreement when one of them shot the other.
Police are now tracking down a relative, who they believe is a person of interest.
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The cause of the alleged dispute remains unknown.