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The shooting happened on Monday at a home on Guston Hall Lane. According to authorities, the boys' uncle, Francisco Lupian, was visiting when his 9-year-old nephew got a hold of his gun and shot the 4-year-old.
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The 4-year-old boy was taken to Memorial Hermann Hospital in Katy by family members and was later transported to the Texas Medical Center via Life Flight.
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The boy was listed in critical condition until his death was announced on Thursday.
Lupian, 32, has since been arrested and charged with possession of a firearm by a convicted felon. He's accused of leaving an unsecured firearm out.