It happened just after 3 a.m. on the Southwest Freeway feeder and Fountain View.
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A woman who police said they believe was intoxicated ran a red light on the northbound feeder road and slammed into another car, according to HPD.
The driver of the vehicle that was hit died. A passenger in the car was critically injured.
The woman involved was booked into jail on intoxication manslaughter charges, police said.
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The crash was one of several traffic fatalities on Houston roads over the weekend.
Two people died in a fiery wrong-way crash on the Southwest Freeway at West Belfort.
Another fatal crash happened in northwest Harris County involved one death and another person who was taken to a hospital by ambulance. That crash happened in the 39400 block of US-290 Business at Stokes Road early Sunday morning.