It happened around 1 a.m. on Westheimer near Hillcroft.
The victim was walking in the middle of the road when a driver struck him, according to Houston police.
Investigators said they do not believe impairment was a factor in the crash and that it appeared to be a tragic accident.
There was no word on the victim's identity in the Saturday morning incident.
Just a day before, a person was taken into custody after a fatal crash a block away.
Houston police say a woman was trying to cross Westheimer on Friday morning near Stoney Brook when she was hit by a car.
The pedestrian was pronounced dead at the scene.
The driver pulled into a convenience store and contacted police.
The female driver was suspected of driving under the influence and will be charged with DUI, police say.
SEE ALSO: Driver suspected of DUI after woman hit and killed while trying to cross Westheimer