It happened in the 2100 block of Ridgemore Drive in the Spring Branch East area on Sunday morning.
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Around 10:30 a.m., the Houston Police Department said they received a call about sounds of a gun being shot in the area.
Upon arriving, police said they saw the off-duty Harris County Sheriff's Office deputy sitting in a white truck with a gun.
Officers said they told the deputy to give up the gun and surrender, which the deputy eventually did. He was then taken into custody.
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HPD told ABC13 the deputy also called the department asking for assistance, and he may have been hallucinating before firing his weapon.
WATCH: HPD says HCSO deputy had 'mental episode' in NW Houston shooting
HPD: HCSO deputy had 'mental episode' in NW Houston shooting
No injuries were reported, according to authorities. HPD's homicide division continues to investigate.