The accident happened Tuesday at about 11:45 a.m. on US-290 near Antoine.
The video shows an 18-wheeler veer into another lane, striking one car and sending it across the freeway out of control.
That vehicle struck another vehicle and rolled over three times on the freeway.
The Houston Police Department said one person was transported to the hospital.
The investigation into the accident is ongoing.
Truck ran red light near 290 and killed 79-year-old passenger: Police
Truck ran red light and killed 79-year-old: Police
CAUGHT ON CAMERA: Watch as a driver loses control on 610
Trailer caught losing control on 610 prompts terrifying screams from others