Harris County sheriff's deputies said the crash happened at about 11 p.m. in the 12800 block of Crosby Lynchburg Road.
When deputies arrived at the scene, they reportedly found a man lying in the roadway. He was pronounced dead at the scene.
Investigators said the man was riding his bicycle northbound on Crosby Lynchburg when an unknown vehicle hit him from behind and fled the scene.
Deputies said evidence at the scene suggests the suspect drove a dark-colored truck or van, though the exact make and model are unknown.
Investigators were reviewing surveillance video in the area. Officials said there are no known witnesses.