The deadly crash happened around 11:44 p.m. Tuesday in the 14100 block of the East Freeway feeder road near Hollywood Cloverleaf.
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Harris County sheriff's deputies found a man dead near a bicycle.
Investigators say the man was riding his bike in the westbound feeder road lanes when he was hit from behind.
The suspect drove off after the crash without stopping, deputies said.
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Investigators are looking for surveillance video in the area to determine what exactly led up to the crash.
"We believe there might possibly be some [cameras] in the area," Deputy Ryan Belvin said. "We'll have to do some follow up with that."
Officials had not yet released a description of the suspect.