Festivities started days before the game when fans and city officials welcomed the team at Hobby Airport.
There was an event at city hall, followed by a parade in downtown Houston.
Several of the Colt .45 players, including Hal Smith, Bobby Shantz, Jim Golden, and Bob Bruce, rode in one of the parade cars.
On opening day, bands played to a packed stadium.
Related: HIghlights from Houston's first major league baseball game.
Highlights from Houston's first MLB game
The Colt .45s beat the Cubs 11-2. Houston's Bob Aspromonte delivered the first hit and scored the first run. Colt .45's right fielder Roman Mejias delivered the power with two 3-run homers, and Bobby Shantz pitched a complete game.