The incident happened in the 8400 block of Nairn Street near Gessner Road.
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According to witnesses, a man driving a truck traveling at a high rate of speed allegedly struck the 2-year-old boy, according to HPD.
The driver attempted to flee, but neighbors nearby were able to stop and hold him until officers arrived, police said.
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According to HPD, the suspect in the case is 22 years old.
This fatal incident was one of two that occurred on Saturday involving a motor vehicle and the death of a young child.
A 6-year-old was stuck and killed by a driver in a white SUV in the 9700 block of Leawood at Elmcroft Drive, also in southwest Houston, at about 6:19 p.m.
Officials are evaluating to determine if alcohol was a contributing factor for both cases.