It happened just after 3 a.m. near downtown.
Police said a driver struck a woman walking along the southbound lanes of Highway 59. It's unclear if she was crossing over the highway or walking along the lanes of traffic.
The female driver stopped and called police.
Investigators said the driver was not intoxicated and she is not expected to be charged.
The area had been shut down for two or three hours but has since reopened.
Update on woman struck and killed on highway 59 pic.twitter.com/QqTFlCsJiy— Jeff Ehling (@JeffEhlingABC13) September 3, 2018