The crash happened in the southbound lanes of I-91 near exit 21 in Middletown.
Connecticut State Police said the crash involved at least 20 cars, 3 tractor trailers and a tanker truck. No serious injuries were reported.
If you're viewing on our ABC13 news app, tap on the photo above to see more images.
Troopers posted this video of the scene on social media:
Interstate 91 south was shut down between exit 21 and exit 25 for more than five hours.
The state police reported multiple crashes and spin-outs across the state.