With the win, Houston takes sole possession of first place in the American Athletic Conference with just seven games remaining.
Corey Davis Jr. and Dejon Jarreau led the way for the Coogs with 16 points each. Galen Robinson Jr. added in 10 points, four rebounds, three assists and one block.
Winners of eight straight games, Houston now moves to 23-1 on the season.
Houston also managed to hold Cincinnati to 33 percent shooting on Sunday, making it the 14th time in 17 home games the Coogs have held an opponent to under 40 percent shooting.
Up next for the Cougars is a Valentine's Day showdown versus the 13-11 UConn Huskies.
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