The Suns said Bledsoe, the team's leading scorer, would have an MRI.
Bledsoe went down with 7:40 left in the second quarter and the Suns trailing 37-25.
He appeared to collide with the 76ers' Robert Covington with the Suns on offense. Bledsoe sat on the floor while the Sixers had a possession at the other end, calling for teammates to foul.
Trainers attended to Bledsoe and helped him off the court and back to the locker room. The guard wasn't able to put any weight on his left leg as he was helped off.
Bledsoe had four points and two rebounds in eight minutes. He entered the game averaging 20.9 points.