Harden left Friday's win over the Timberwolves in the third quarter after taking a knee from Karl-Anthony Towns to his thigh. He was limping badly but returned in the fourth quarter, finishing with 12 points and five assists.
D'Antoni said Harden is also considered doubtful to play Monday against the Utah Jazz. D'Antoni also added that Russell Westbrook will sit that game out as well.
This marks the second game Harden has missed this season. He also sat out a loss in New Orleans on Dec. 29.
Harden is averaging 36.1 points to lead the league and has scored 40 or more points 16 times. The Rockets are 14-2 when he does.
The Associated Press contributed to this report.
Iverson: Harden doesn't deserve criticism for his game
Allen Iverson joins The Jump and defends James Harden, saying his offensive style should be praised, not criticized.