The Astros said he had "left lower leg discomfort,'' and manager Dusty Baker said Odorizzi would get an MRI. The pitcher was on crutches, in a boot and in good spirits after the game, Baker said.
"He's probably doing better than it looked like on the mound,'' Baker said.
Odorizzi, who entered the game with a 15 inning shutout streak, appeared to twist his left leg awkwardly on the delivery to Kike Hernandez. When he turned to cover first base, he took a step and then sprawled out, face down, on the grass.
He remained there after the out was recorded, and Astros staff rushed to tend to him. He was loaded onto a stretcher and wheeled off to an outfield exit. Astros teammates hovered around the infield as the stretcher arrived.
The 32-year-old veteran entered the game with a 3-2 record this season to go along with a 3.38 ERA and 17 strikeouts. The Red Sox led 2-1 when he left. The game was tied at 2-2 in the sixth inning when it was delayed by rain.
The Associated Press contributed to this report.
Jake Odorizzi carted off after apparent injury
Jake Odorizzi was carted off against the Red Sox after an apparent leg injury in the fifth inning.