Former top Astros prospect Jon Singleton and Houston pitcher Dean Deetz have been suspended after testing positive for banned drugs.
Deetz became the first player penalized this year under the major league drug program. Singleton was the eighth under the minor league program.
The commissioner's office announced the penalties Tuesday.
Deetz drew an 80-game ban for a positive test of Dehydrochlormethyltestosterone, a performance-enhancing substance.
Deetz has never played in the majors but is on Houston's 40-man roster. The 24-year-old righty was 7-6 with a 4.25 ERA last year as a starter and reliever at Triple-A Fresno and Double-A Corpus Christi.
In a statement released by the players' union, Deetz said, "I have no idea how I could possibly have tested positive."
Singleton was banned 100 games after a third positive test for a drug of abuse. The 26-year-old first baseman played 114 games for Houston in 2014-15, hitting .171 with 14 home runs. Singleton spent last year at Double-A, batting .205 with 18 homers.
Prior to reaching the majors, in an interview with The Associated Press, Singleton spoke of his battle to overcome marijuana and alcohol abuse.
Former top Astros prospect Singleton, Deetz banned for drugs